From the Instructions to King Prthu.
Sri Caitanya Mahaprabhu has especially stressed protection from offenses unto the lotus feet of Vaisnavas. Such offenses are called vaisnava-aparadha. Aparadha means "offense." If one commits vaishnava-aparadha, all of his progress in devotional service will be checked. Even though one is very much advanced in devotional service, if he commits offenses at the feet of a Vaisnava, his advancement is all spoiled. In the sastras it is found that a very great yogi, Durvasa Muni, committed a Vaisnava-aparadha and thus for one full year had to travel all over the universe, even to Vaikunthaloka, to defend himself from the offense. At last, even when he approached the Supreme Personality of Godhead in Vaikuntha, he was refused protection. Therefore one should be very careful about committing offenses at the feet of a Vaisnava. The most grievous type of vaisnavaaparadha is called guru-aparadha, which refers to offenses at the lotus feet of the spiritual master. In the chanting of the holy name of the Supreme Personality of Godhead, this guruaparadha is considered the most grievous offense. Sri Caitanya Mahaprabhu has described the vaisnavaaparadha, or offense to a Vaisnava, as "the mad elephant offense." One should be very careful not to offend a Vaisnava or a brahmana. Even the great yogi Durvasa was harassed by the Sudarsana cakra when he offended the Vaisnava Maharaja Ambarisa, who was neither a brahmana nor a sannyasi but an ordinary householder. Maharaja Ambarisa was a Vaisnava, and consequently Durvasa Muni was chastised.

The conclusion is that if Krsna consciousness is covered by material sins, one can eliminate the sins simply by chanting the Hare Krsna mantra, but if one pollutes his Krsna consciousness by offending a brahmana or a Vaisnava, one cannot revive it until one properly atones for the sin by pleasing the offended Vaisnava or brahmana. A vaisnavaaparadha cannot be atoned for by any means other than by begging the pardon of the offended Vaisnava,